98 points by AndrewDucker 3 days ago | 115 comments | View on ycombinator
mlboss 3 days ago |
tancop 3 days ago |
Of course it's not easy, not everyone can do it (like if they also have some intellectual disability) or wants to do it, but it's the right solution for a lot of people. It's not really curing autism because it's not changing your DNA but it's definitely treating the most socially disabling symptoms.
But I think the statements all good and does what it's supposed to if it helps fight forced therapy child abuse and anti vax movements. Don't need to be perfect to make a change.
zug_zug 3 days ago |
Also it clearly must be to some degree mutations if you believe the rates are going up, which even the government is no longer disputing (though that may not be conclusive proof, to me it seems evidence leans to more likely than not currently).
De novo mutations can also be caused by environmental factors, this is very well established and called "genotoxicity"[1] and certainly some people have been exposed to known genotoxic chemicals to varying degrees over time (formaldehyde) and who knows what undiscovered ones there are, newer standards of pesticide testing are starting to look for reproductive health effects but many chemicals that have been in use for a long time haven't been held to the highest standard.
Another reason you might think it would be "de novo" mutations is that this could be any sorts of random errors in the genome. If autism is an umbrella label for various genome errors (which it very well may be, since it correlates with other conditions very often), that may explain why it's so hard to pin down a few genes and why symptom expression varies so drastically.
profsummergig 3 days ago |
Here's one: even if it were genetic, there could be triggering environmental factors that trigger the onset of autism (I'm just giving a hypothetical example, not making a claim here).
erelong 3 days ago |
> We don't fully understand how genes combine to make a person autistic.
Llamamoe 3 days ago |
There are very strong reasons to suspect that gut microbiome at least plays a major role in at least a large portion of autism cases, complete with studies where we've been able to induce/reverse a subset of autism symptoms in mice, and even humans, as well as linking individual gut microbe metabolites to them. And ~80% of autistic people have gut problems.
There's no question in my mind that at least some of the propensity to develop autism is genetic, but calling the whole of it genetic feels ridiculous in the face of preliminary evidence to the contrary consistent with the massive increase in diagnosis rates beyond what can be explained by changing criteria.
OutOfHere 2 days ago |
If you want the truth, here is the science:
Plasticizer exposure during pregnancy linked to increased autism- and ADHD-related symptoms in children (2026)
https://medicalxpress.com/news/2026-09-plasticizer-exposure-...
https://dx.doi.org/10.1016/j.medj.2026.101291
Basically, environmental harm during pregnancy via plasticizer phthalates leads to epigenetic dysregulation which develops the brain defectively. This is distinctly not genetic.
GoToRO 3 days ago |
LoganDark 3 days ago |
It's, I believe, the peer-reviewed version of this preprint from a couple years ago, "Decomposition of phenotypic heterogeneity in autism reveals distinct and coherent genetic programs": https://www.medrxiv.org/content/10.1101/2024.08.15.24312078v...
Essentially, there are four types of autism! I think they deserve to be known more individually rather than having only one "autistic spectrum". Ever since seeing the preprint I've practiced telling the different types apart, it's been very interesting.
threethirtytwo 3 days ago |
NamlchakKhandro 3 days ago |
la6479 3 days ago |
treebeard901 3 days ago |
mrbluecoat 2 days ago |
Psst, words like "most", "often", and "usually" aren't helping your "vague" problem.
bronlund 3 days ago |
undefined 3 days ago |
mitxela 3 days ago |
deadlast2 3 days ago |
Ylano 3 days ago |
brewcejener 3 days ago |
jmspamerton 3 days ago |
lioeters 3 days ago |
Autism is genetic but we cannot do genetic testing and prove that you have autism. Seems like a very circular reasoning.