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Autism is genetic – and why this information matters now (https://www.autism.org.uk)

98 points by AndrewDucker 3 days ago | 115 comments | View on ycombinator

mlboss 3 days ago |

> Autism is genetic. You’re born autistic and you’re autistic for life. Most autistic people are autistic because of genes they got from their parents. This is why autism often runs in families. Much less commonly, other factors can play a role, but usually in combination with genes from parents. There isn’t a single ‘autism gene’. Thousands of genes combine to make a person autistic. Scientists have identified many of these genes, but they think there are still many more to find. And there is no genetic test for autism. We don't fully understand how genes combine to make a person autistic. It is complex and no simple test can give an accurate answer. Genetic testing cannot predict whether a child will be autistic or not, and it can’t be used to diagnose someone as autistic.

Autism is genetic but we cannot do genetic testing and prove that you have autism. Seems like a very circular reasoning.

tancop 3 days ago |

The part about being autistic for life is not really helpful. I personally know people who learned to "stop being autistic" from an outside POV, and they got to the point where they're not consciously masking anymore, it all comes natural. Just decided to act "normal" for a change and stuck with it.

Of course it's not easy, not everyone can do it (like if they also have some intellectual disability) or wants to do it, but it's the right solution for a lot of people. It's not really curing autism because it's not changing your DNA but it's definitely treating the most socially disabling symptoms.

But I think the statements all good and does what it's supposed to if it helps fight forced therapy child abuse and anti vax movements. Don't need to be perfect to make a change.

zug_zug 3 days ago |

I feel like this is a willfully confusing article. So autism may involve disrupted genetics, but you may not have inherited those genes from your parents, they may be what are called "de novo mutations" which are mutations to the sperm or egg cells in the parent. This is evidenced by autism being more prevalent when the parents are older and those mutations are more common.

Also it clearly must be to some degree mutations if you believe the rates are going up, which even the government is no longer disputing (though that may not be conclusive proof, to me it seems evidence leans to more likely than not currently).

De novo mutations can also be caused by environmental factors, this is very well established and called "genotoxicity"[1] and certainly some people have been exposed to known genotoxic chemicals to varying degrees over time (formaldehyde) and who knows what undiscovered ones there are, newer standards of pesticide testing are starting to look for reproductive health effects but many chemicals that have been in use for a long time haven't been held to the highest standard.

Another reason you might think it would be "de novo" mutations is that this could be any sorts of random errors in the genome. If autism is an umbrella label for various genome errors (which it very well may be, since it correlates with other conditions very often), that may explain why it's so hard to pin down a few genes and why symptom expression varies so drastically.

1. https://en.wikipedia.org/wiki/Genotoxicity

profsummergig 3 days ago |

So many misconceptions in this writeup.

Here's one: even if it were genetic, there could be triggering environmental factors that trigger the onset of autism (I'm just giving a hypothetical example, not making a claim here).

erelong 3 days ago |

"They think" autism is genetic and that would be fine as a title, but they have not proven it is (only or even mostly) genetic

> We don't fully understand how genes combine to make a person autistic.

Llamamoe 3 days ago |

Heritable != genetic.

There are very strong reasons to suspect that gut microbiome at least plays a major role in at least a large portion of autism cases, complete with studies where we've been able to induce/reverse a subset of autism symptoms in mice, and even humans, as well as linking individual gut microbe metabolites to them. And ~80% of autistic people have gut problems.

There's no question in my mind that at least some of the propensity to develop autism is genetic, but calling the whole of it genetic feels ridiculous in the face of preliminary evidence to the contrary consistent with the massive increase in diagnosis rates beyond what can be explained by changing criteria.

OutOfHere 2 days ago |

The article is shamelessly false and misleading.

If you want the truth, here is the science:

Plasticizer exposure during pregnancy linked to increased autism- and ADHD-related symptoms in children (2026)

https://medicalxpress.com/news/2026-09-plasticizer-exposure-...

https://dx.doi.org/10.1016/j.medj.2026.101291

https://youtu.be/j4Tz86TENvs

Basically, environmental harm during pregnancy via plasticizer phthalates leads to epigenetic dysregulation which develops the brain defectively. This is distinctly not genetic.

GoToRO 3 days ago |

Autism looks to me similar to what a guy had when we were children. His mother was known for drinking even durring pregnancy. I'm pretty sure that we are disrupting some development mechanism today with all the substances we consume, even without knowing. Food, cosmetics, clothes, the air and so on. I think this onslaught on our bodies is what disrupts normal body functioning, in unpredictable ways. Combine that with pregnancy and the disruptions get written in "hardware". So no real cure, maybe some improvements. At government levels I think this is known, but they don't know what to do about it. Giving people a clean environment again, will have to undo most of the "progress" we got. Anyway, this is just my hunch but at individual level is better not to wait for 100% scientific confirmation.

LoganDark 3 days ago |

I would encourage anyone interested in autism to take a look at this paper, "Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs": https://www.nature.com/articles/s41588-025-02224-z

It's, I believe, the peer-reviewed version of this preprint from a couple years ago, "Decomposition of phenotypic heterogeneity in autism reveals distinct and coherent genetic programs": https://www.medrxiv.org/content/10.1101/2024.08.15.24312078v...

Essentially, there are four types of autism! I think they deserve to be known more individually rather than having only one "autistic spectrum". Ever since seeing the preprint I've practiced telling the different types apart, it's been very interesting.

threethirtytwo 3 days ago |

If you read the article it says they don’t know what genes influences autism. That means they don’t know. They established correlation but not causation. Could be the causative factor is environmental and genes simply makes a person more vulnerable to that causative factor.

NamlchakKhandro 3 days ago |

I think Claude is not autistic enough

la6479 3 days ago |

THis is where rubber meets the road. Show me how AI can make life easier for autistic people and their caregivers , mentally challenged people and their caregiver and I will believe in the promise of AI.

treebeard901 3 days ago |

It's an evolutionary trait that is in response to increasing use of electronics and computers. As being good with technology is a larger part of survival of the fittest, the autism traits will only increase along with it.

mrbluecoat 2 days ago |

> Until recently, ideas about what causes autism have been vague, and this sense of uncertainty has allowed misinformation to escalate. ... Autism is genetic. You’re born autistic and you’re autistic for life. Most autistic people are autistic because of genes they got from their parents. This is why autism often runs in families. Much less commonly, other factors can play a role, but usually in combination with genes from parents.

Psst, words like "most", "often", and "usually" aren't helping your "vague" problem.

bronlund 3 days ago |

Trust the science! :D

undefined 3 days ago |

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mitxela 3 days ago |

Headline is obviously AI slop

deadlast2 3 days ago |

I lived in New York 2004 to 2009. 2006 I think there was this epidemic in cases when I say everyone had kids who were autistic I am not even exagerating. I was one. Was like a movie I dont think I could exagerate what happened it was everywhere all at once. It was vaccines everyine knew it everyone still does. These people are liars. They were then they still are dont believe them.

Ylano 3 days ago |

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brewcejener 3 days ago |

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jmspamerton 3 days ago |

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lioeters 3 days ago |

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